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Drug Expiration Dates - Are Expired Drugs Still Safe to Take?
The Dating Game
The box of prescription drugs had been forgotten in a back closet of a retail pharmacy for so long that some of the pills predated the moon landing. Most were 30 to 40 years past their expiration dates — possibly toxic, probably worthless. But to Lee Cantrell, who helps run the California Poison Control System, the cache was an opportunity to answer an enduring question about the actual shelf life of drugs: Could these drugs from the bell-bottom era still be potent? Cantrell called Roy Gerona, a University of California, San Francisco researcher who specializes in analyzing chemicals. Gerona grew up in the Philippines and had seen people recover from sickness by taking expired drugs with no apparent ill effects. The age of the drugs might have been bizarre, but the question the researchers wanted to answer wasn't.
SLEP is administered by the U. Department of Defense DoD in cooperation with the U. The purpose of SLEP is to defer replacement costs of stockpiled drugs by extending their useful life.
Pharmaceutical ingredients are controlled by cGMP regulations. Users of pharmaceutical materials should be informed regarding when the material can be re-tested for continued use. After this period, a batch of drug substance destined for use in the manufacture of a drug product should be retested for compliance with the specification and then used immediately. A batch of drug substance can be retested multiple times and a different portion of the batch used after each retest, as long as it continues to comply with the specification.